乙型肝炎患者血清HBVDNA负荷与其肝功能及肝组织损害的关系研究

Researeh on the correlation between the contents of serum HBV DNA and liver function and liver tissue injury in hepatitis B patients.

探讨乙肝患者血清HBVDNA含量与其肝功能及肝组织损害的关系。检测 380例未经治疗的乙肝患者血清HBVDNA、肝功能 ,其中 71例进行了肝活检。乙肝患者血清HBVDNA含量与其病情的严重程度不一致 ;临床各型乙肝中HBVDNA阳性组与阴性组间ALT、TBil均无显著差异 (P >0 0 5 ) ;肝组织炎症分级Gi～G4和纤维化分期S1～S4各组间HBVDNA值均无明显差异 (P >0 0 5 )。乙肝患者血清HBVDNA含量不能反映其病情的临床严重程度 。

To evaluate the serum HBV DNA level in hepatitis B and its relation with liver function and liver tissue injury.380 untreated patients with hepatitis B were selected and their serum HBVDNA level and liver function were detected,and among them 71 cases received liver biopsy.Serum HBVDNA level disaccord with state of their illness;serum ALT and TBil in those HBVDNA(+)and HBVDNA(-) have no difference (P>0.05);HAI scores have no relation with serum HBVDNA level(P>0.05).Serum HBVDNA level cannot reflect the state of hepatitis illness,and no correlation with inflammation and fibrosis in liver.