肝硬化患者尿Crosslaps检测在骨代谢异常诊断中的价值

The diagnostic value of bone abnormal metabolism by urine crosslaps in patients with posthepatitic cirrhosis

为探讨尿骨胶原胶联 (Crosslaps)、尿钙离子 /肌酐 (Ca2 + /Cr)与肝硬化骨代谢异常的关系。分别测定 6 1例乙肝后肝硬化患者尿Crosslaps水平、尿Ca2 + /Cr及骨密度测量 ,并与 30例健康者对照。结果表明 ,肝硬化组尿Crosslaps水平较对照组明显升高 (P <0 0 1) ,其中骨质疏松 (OP)组与非骨质疏松 (NOP)组比较有明显差异 (P <0 0 5 ) ,且OP组尿Crosslaps水平与尺桡密度呈负相关 (r=- 0 4 33,P <0 0 1)。尽管OP组尿Ca2 + /Cr较NOP组升高 (P <0 0 1) ,但与尺桡密度无相关性 (r =- 0 2 37,P >0 0 5 )。提示尿Ca2 + /Cr不能作为肝硬化骨吸收指标 。

To investigate the relationship between urine crosslaps,urine Ca 2+/Cr and hepatic bone disease(HBD),levels of urine crosslaps and urine Ca 2+/Cr were detected in 61 male cirrhosis and 30 age-matched healthy controls.The results showed that urine crosslaps levels of cirrhosis increased more than that of controls (P<0.01),and osteoporosis(OP)group's much higher than non-osteoporosis(NOP)group's(P<0.05).We also found urine crosslaps had negative correlation with mean ulnoradial density(r=-0.433,P<0.01).Although urine Ca 2+/Cr in OP group was much higher than that in NOP group(P<0.01),no correlation was found with mean ulno-radial density (r=-0.237,P>0.05).These dates suggested that urine Ca 2+/Cr is not an useful bone absorptive index to HBD.The variation of urine crosslaps in patients with posthepatitic cirrhosis may play an important role in diagnosis HBD.