CA242、CA19-9、CA125对胰腺癌的诊断价值

Diagnostic value of serum levels of CA242,CA19-9 and CA125 to patients with pancreatic cancer

目的 :探讨肿瘤标志物 CA2 4 2、CA19- 9、CA12 5对胰腺癌的诊断作用。方法 :测定胰腺癌病人 4 2例、良性胰腺疾病 14例 ,肝胆系统良性疾病 34例及其它恶性肿瘤 2 6例 ,正常对照 36例的 CA2 4 2及 CA19- 9、CA12 5血清水平。结果 :在胰腺癌组病人中 CA2 4 2及 CA19- 9血清值显著升高。CA12 5血清水平则在胰腺癌组肝癌等恶性肿瘤组及胰腺良性病变组中均显著升高 ,CA2 4 2、CA19- 9及 CA12 5血清水平在胰腺癌不可手术切除明显高于可手术切除组(P<0 .0 5 ) ,敏感性方面 :CA19- 9为 85 .71% ,CA2 4 2为 76 .19% ,CA12 5为 6 6 .6 7%。特异性方面 :CA2 5 2为 87.84 % ,CA19- 9为 72 .97% ,CA12 5为 74 .74 % ,以不同组合方式联检 ,敏感性、特异性有所增加 ,其中以 CA2 4 2 +CA19- 9联检增加幅度较大。结论 :胰腺癌肿瘤标志物 CA2 4 2、CA19- 9可作为早期诊断胰腺癌的有力工具 ,其中 CA 2 4 2特异性显著好于 CA19- 9,单检 CA12 5对胰腺癌的诊断价值不大 ,测定 CA19- 9、CA2 4 2有助于评价胰腺癌的手术可切除性及预后。 CA19- 9+CA2 4 2是优选的联检组合方式 ,联检 CA2 4 2、CA19-

Objective:To investigate the diagnostic Value of serum levels of CA242,CA19-9 and CA125 to Pancreatic cancer.Methods:Total plasma levels of CA242 were measured by IRMA methods,and CA19-9 and CA125 were measured by CLIA methods in blood samples from 36 healthy donors and 116 patients with PC,benign pancreatic lesions,benign hepatobiliary diseases and other malignancies,and their diagnostic value were assessed.Results:The patients with PC had significantly elevated CA242 and CA19-9 serum levels.CA125 serum levels were elevated in patients with pc or in patients with benign pancneatic lesions and with other malignant diseases. The serum levels of CA242,CA19-9and CA125 in non-resectable patients with PCwere significantly higher than that in patients with resectable PC(P<0.05).With these commended cutoffs(22u/ml for CA242,37u/ml for CA19-9and 35u/ml for CA125),we obtained a sensitivity of 76.19% for CA242,85.71%for CA19-9and 66.67%for CA125;The specificity was 87.84%、72.97% and 74.74% for CA242,CA19-9 and CA125,respectively. Combining CA242and CA19-9 measurements increased the sensitivity and specificity obtained from CA242 or CA19-9 alone.Conclusions:CA242 and CA19,because of their high sensitivity and specificity,may be considered as markers for the assessment of resectablity of tumour and prognosis of PC. CA242 has a higher specificity than CA19-9. Combiming CA242and CA19-9 measurements is a excellent combined fashion and can greatly enhance the diagnosis of patients with PC.