MRI的白质高信号与帕金森病的临床相关性研究(英文)

Clinical correlations between white matter hyperintensities on MRI and Parkinson′s Disease

目的探讨MRI的白质高信号与帕金森病(Parkinson'sdisease,PD)的临床特征之间的关系。方法对90例PD患者和60例年龄匹配的健康对照者进行MRI检查,对比分析PD组和对照组中MRI的白质高信号(包括侧脑室周围和半卵圆中心的白质高信号)的发生率,并研究白质高信号和PD的病程和病情等临床特征之间的关系。结果PD组比对照组侧脑室周围白质高信号的发生率明显增高(P<0.05),并且有侧脑室周围白质高信号的PD患者比无侧脑室周围白质高信号的PD患者具有更短的病程和更严重的病情(P<0.05)。但是,PD组的半卵圆中心白质高信号的发生率与对照组无明显差异(P>0.05),并且有卵圆中心白质高信号的PD患者的病程和病情与无半卵圆中心白质高信号PD患者无明显差异(P>0.05)。结论侧脑室周围白质高信号也许是PD的一个具有更快神经变性过程的临床亚型的标志。

To explore possible correlation between the white matter hyperintensities on MRI and clinical features of Parkinson′s disease (PD). 90 patients with PD and 60 age-matched healthy controls were imaged by MRI, and the frequencies of both periventricular and centrum semiovale hyperintensities were analyzed and compared. Moreover, in the PD group, we studied the possible correlation of the white matter hyperintensities with clinical features such as severity and disease duration. The frequency of the periventricular hyperintensities was significantly higher in patients with PD than people in healthy control (P<0.05). However, there were no significant differences in the frequency of centrum semiovale hyperintensities found between patients with PD and healthy control (P>0.05). Moreover, within the PD group, the patients with periventricular hyperintensities had significantly shorter disease duration and greater disease severity than those without (P<0.05); but no significant differences were found between patients with or without centrum semiovale hyperintensities either in disease duration or in disease severity (P>0.05). [Conclusion] These data suggest that periventricular hyperintensities may be a marker for a clinical subtype of PD characterized by a faster neurodegenerative process.