膀胱癌术后吡柔比星膀胱灌注预防复发临床观察

Intravesical instillation of pirarubicin for preventing postoperative recurrence of bladder cancer

目的探讨膀胱癌术后复发的有效预防方法。方法手术治疗37例膀胱癌患者,术后用吡柔比星(THP)膀胱灌注治疗,并做随访和疗效观察。结果所有患者均获6～24个月的随访,复发6例,复发率为16.2%,并发症和副作用较轻。结论THP膀胱灌注预防膀胱癌术后复发有较好的疗效,且毒副作用少。

To investigate the effect of intravesical instillation of pirarubicin on the postoperative recurrence of bladder cancer. 37 postoperative cases of bladder carcinoma were treated with intravesical instillation of pirarubicin and the prophylactic effects on the recurrence were observed. The duraion of follow-up was 6～24 months. The result showed the recurrence rate was 16.2% and the side effect was negligible. It is proved that pirarubicin administaered prophylactically after TURBT or operation of bladder tumor was effective and better tolerated than other chemotherapeutic agents. [Conclusion] Postoperative intravesical installition of pirarubicin for bladder tumor has good prophylactic effects on the recurrence without heavy side effects.