4Kanaji T, Kanaji S, Osaki K, et al. Identification and characteriza- tion of two novel mutation (Q421K and R123P) in congenital fac- tor Ⅻ deficiency. Thromb Haemost ,2001,86(6) : 1409-1415.
5McMullen BA, Fujikawa K. Amino acid sequence of the heavy chain of human a-factor Ⅻa( activated Hageman factor). J Biol Chem, 1985,260 (9) :5328-5341.
6Sofia JM, Almasy L, Souto JC, ct al. A Quantitative-trait locus in the human factor Ⅻ hehe influences both plasma factor Ⅻ levels and susceptibility to thrombotic disease. Am J Hum Genet,2002, 70(3) :567-574.
7Colhoun HM, Zito F, Chan NN, et al. Activated factor Ⅻ levels and factor Ⅻ 46C/T genotype in relation to coronary artery calcification in patients with type 1 diabetes and healthy subjects. Atherosclero- sis,2002,163 (2) :363-369.
8Kanaji T, Okamura T, Osaki K, et al. Common genetic polymor- phism(46C to T substitution) in the 5'-untranslated region of the coagulation factor Ⅻ gene is associated with low translation effi- ciency and decrease in plasma factor Ⅻ level. Blood, 1998,91 (6) :2010-2014.
9Zito F, Lowe GD, Rumley A, et al. Association of the factor Ⅻ 46C > T polymorphism with risk of coronary heart disease (CHD) in the WOSCOPS stugy. Atherosclerosis ,2002,165 : 153.
10Schmaier AH, LaRusch G. Factor Ⅻ : new life for an old protein. Thromb and Haemost,2010,104(5 ) :915-918.
