诺氟沙星明胶磁性微球的研制及表征

Preparation and Characterization of Magnetic Nornoxacin Gelatin Microspheres

利用明胶的生物相容性及经戊二醛处理可使其固化的特性,以Fe3O4作为磁性内核,以液体石蜡为有机分散介质,通过反相悬液冷冻凝聚法制备了强磁性的诺氟沙星明胶核壳微球,用IR、SEM、TEM、UV／Vis等技术对微球进行了性能表征,结果表明:微球成球性好,无粘连,平均直径为5-10μm,Fe3O4的含量为19％,明胶的含量为74.8％,微球载药率(w／w)为6.2％,药物包裹率为61.4％,5h释放药物为74.4％,微球具有较好的缓释性.

Based on the biological compatibility of gelatin in water and its solidification by glutaradehyde, the magnetic norfloxacin gelatin core-shell microspheres were prepared by means of the reverse phase suspension cold-condensation method using Fe3O4 as core and glutaric dialdehycle as dispersed medium. The products were characterized by IR, SEM, TEM, UV/Vis. The results show that the microspheres are spherical in shape with smooth surfaces. The diameter of the microspheres is in the rang from 5 to 10mum, The content of drug in microspheres is 6.2% and of Fe3O4 is 19%. The drug encapsulation efficiency is 61.4%, the quantity of drug released from microspheres in 5 hours is 74.4%. The microspheres have good properties of drug sustain releasing.