葡聚糖中超顺磁氧化铁复合纳米粒子制备影响因素及表征

Influence of Preparation Parameters and Characterization of Nano-compound Superparamagnetic Iron Oxide Particle in Dextran System

利用化学共沉积法在改性葡聚糖体系下制备了以超顺磁性纳米氧化铁为核心,外包葡聚糖的壳核结构复合粒子.对制备过程控制因素进行了详细的研究,实验结果表明:利用改性葡聚糖为表面活性剂,碱源快速滴加,合理的控制反应时间,温度可形成小核的超顺磁性纳米氧化铁-葡聚糖复合纳米粒子.在优化的实验条件下,得到核心的平均粒径5nm,总体的平均粒径为7.8nm,并利用XRD、TEM和GLS等手段对其结构,形态和粒径分布进行了表征.

Compound nano-particles of the superparamagnetic iron oxide, which are core-shell structure with iron oxide as core and dextran as shell, were prepared in the single-carboxyl dextran water-base solution by a chemical co-deposition method. The factors of controlling the processing were investigated systematically. The compound particle's morphology and microstructure and the distribution of particale diameters were investigated by means of XRD, TEM and GLS. The resultes show that the diameter of the compound nano particle can be decreased by accurately controlling the modification dextran quantity added, the drip-speed of NH4OH and the reaction time as well as reaction temperature. Under the conditions of optimum parameters, the core-shell compound structure particle average diameter is 7.8nm, the average core diameter of iron oxide is 5nm and the thick of dextran shell is 1similar to1.5nm.