摘要
目的 建立单室模型药物血管外给药零级释放和一级释放的药物动力学,探讨以剂型中药物的释放动力学和活性药物固有的吸收、分布、清除动力学参数为基础的血管外给药零级释放和一级释放血药动力学。方法 以拉氏变换解微分方程和隔室模型分析等经典的药物动力学方法,分析单室模型药物血管外给药零级释放和一级释放在释放阶段和释放完成后的药物动力学。结果 得到了零级释放和一级释放在释放期间和释放结束后的血药动力学。结论 建立了单室模型药物血管外给药零级释放和一级释放的药物动力学。由于零级释放与一级释放是基本的释放模式,零级释放和一级释放药物动力学理论是建立和理解缓释、控释制剂药物动力学的基础。
Aim To establish the pharmacokinetic principles of the zero-order release and the first-order release of mono-compartment drugs administered by non-parenteral route based on the release kinetics of the dosage forms and the intrinsic pharmacokinetic parameters of the active drug, such as the rate constants of the absorption and elimination, and the distribution volume of the drug. Methods By the Laplace transform and the compartmental analysis method, the pharmacokinetic behaviors of the zero-order release and the first-order release of mono-compartment drugs administered by non-parenteral routes were deduced with divisions of the dose being absorbed during the release phase and after the release has terminated. Results The pharmacokinetics of the non-parenteral administration of the zero-order release and the first-order release of mono-compartment drugs were established. Conclusion The pharmacokinetic theories of the zero-order release and the first-order release of mono-compartment drugs administered by non-parenteral route have been established. Since the zero-order release and the first-order release are the primary release patterns, the theory should be a key to explore the pharmacokinetics of the controlled/sustained release dosage forms.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2005年第2期245-248,共4页
Chinese Pharmacological Bulletin
关键词
零级释放
一级释放
单室模型
药物动力学
缓释
制剂
控释制剂
zero-order release
first-order release
mono-compartment
pharmacokinetics
sustained release
controlled release