水通道蛋白-5在人鼻息肉组织中的表达

Expression and distribution of aquaporin-5 in human nasal polyps

目的探讨水通道蛋白5(aquaporin5,AQP5)在维护正常鼻生理功能及在鼻息肉发病机制中的作用;明确AQP5在下鼻甲和鼻息肉组织中不同部位的表达及分布。方法取30例鼻息肉组织和12例下鼻甲组织,用4%多聚甲醛固定,石蜡包埋,连续切片,应用免疫组织化学技术检测AQP5在下鼻甲黏膜组织和鼻息肉组织中的阳性细胞的表达及分布。结果下鼻甲AQP5的黏膜固有层腺体的阳性细胞表达显著高于鼻息肉组织;而鼻息肉组织AQP5的血管内皮的阳性细胞表达则显著高于下鼻甲黏膜组织。结论AQP5在鼻息肉组织固有层毛细血管及血窦内皮细胞呈过度表达,在腺体表达减少。AQP5在病理状态下对鼻息肉的形成有一定作用。

Objective:To investigate the distribution and expression of aquaporin-5(AQP-5) in nasal polyps and explore the role of AQP-5 in the formation of nasal polyps and the normal function of AQP-5 in the inferior turbinate.Method:AQP-5 were studied in 30 samples nasal polyps and 12 samples of inferior turbinates with immunochemistric staing.Result:The level of AQP-5 positive cells in the serous cells from nasal polyps were lesser than that from inferior turbinate,and the level of AQP-5 positive cells in the blood vessel endothelium from nasal polyps were more than that from inferior turbinate.Conclusion:AQP-5 may play the role in both the formation of nasal polyps and the function of normal nasal mucous membrane.