期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

乙酰肝素酶的生物学特性的研究进展

Reserch Advance on Properties of Heparanase
下载PDF
导出
摘要 乙酰肝素酶是切割哺乳动物细胞中硫酸肝素蛋白多糖侧链———硫酸乙酰肝素的内源性糖苷酶,是抗肿瘤转移的理想靶点。本文就乙酰肝素酶的分子结构特点、亚细胞定位、活性调控机制、与肿瘤转移的关系、底物特异性和抑制剂开发等方面的研究进展进行了综述。 The endo-beta-D-glucuronidase, heparanase, is capable of specifically degrading mammalian heparan sulfate(HS) which links to heparan sulfate proteoglycans(HSPGs). It has been found to be a potential target for antimetastasis drugs. The reserch advance of the molecular properties, the subcellular localization, the regulation of expression and function, the substrate specificity and the specific inhibitors of heparanase were described in here.
作者 凌焱 汤国营 陈惠鹏
机构地区 军事医学科学院生物工程研究所
出处 《生物技术通讯》 CAS 2005年第1期68-70,共3页 Letters in Biotechnology
关键词 乙酰肝素酶 肿瘤转移 内源性糖苷酶 硫酸肝素蛋白多糖 生物学特性 抗肿瘤转移靶点 heparanase metastasis endoglycosidase heparan sulfate proteoglycans
分类号 Q556.2 [生物学—生物化学] R730.5 [医药卫生—肿瘤]
  • 相关文献

参考文献31

  • 1李燕杰,彭清忠.乙酰肝素酶的结构、功能及调控[J].生物技术通讯,2003,14(2):141-144. 被引量：4
  • 2McKenzie E,Young K. Biochemical characterization of the active heterodimer form of human heparanase (Hpa1) protein expressed in insect cells [J].Biochem J, 2003,373(Pt2):423
  • 3Ishida K, Teruya T. Exploitation of heparanase inhibitors from microbial metabolites using an efficient visual screening system[J]. J Antibiot, 2004,57(2):136
  • 4Temkin V,Aingorn H. Eosinophil major basic protein: first identified natural heparanase-inhibiting protein[J]. J Allergy Clin Immunol,2004,113(4):703
  • 5Levy-Adam F, Miao HQ. Heterodimer formation is essential for heparanase enzymatic activity[J]. Biochem Biophys Res Commun, 2003,308(4):885
  • 6Nardella C, Lahm A. Mechanism of activation of human heparanase investigated by protein engineering[J]. Biochemistry, 2004,24,43(7):1862
  • 7Zetser A, Levy-Adam F. Processing and activation of latent heparanase occurs in lysosomes[J]. J Cell Sci. 2004,117(Pt11):2249
  • 8Vlodavsky I, Friedmann Y. Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis[J]. Nat Med, 1999,5:793
  • 9Nadav L,Eldor A. Activation, processing and trafficking of extracellular heparanase by primary human fibroblasts[J]. J Cell Sci, 2002,115:2179
  • 10Levidiotis V,Freeman C. Heparanase is involved in the pathogenesis of proteinuria as a result of glomerulonephritis[J]. J Am Soc Nephrol,2004,15(1):68

二级参考文献38

  • 1[10]Dempsey LA, Brunn GJ, Platt JL. Heparanase: a potent regulator of cell matrix interactions[J]. TIBS, 2000, 25:349
  • 2[11]Hook M, Wasteson A, Olderg A. A heparan suffate.-degrading endoglycosidase from rat liver tissue[J]. Biochem Biophys Res Commun, 1975,67:1422
  • 3[12]Nakajima M, Irimura T, Nicolson GL. Heparanases and tumor metastasis[J]. J Cell Biochem, 1988,36:157
  • 4[13]Bartlett MR, Underwood PA, Parish CR. Comparative analysis of the ability of leucocytes, endothelial cells and platelets to degrade the subendothelial basement membrane: evidence for cytokine dependence and detection of a novel sulfatase[J]. Immunol Cell Biol, 1995,73(2):113
  • 5[14]Oosta GM, Favreau LV, Beeler DL, et al. Purification and properties of human platelet heparitinase[J]. J Biol Chem, 1982,257(19):11249
  • 6[15]Ihrcke NS, Parker W, Reissner KJ, et al. Regulation of platelet heparanase during inflammation: role of pH and proteinases[J]. J Cell Physiol, 1998,175(3):255
  • 7[16]Jin L, Nakajima M, Nicolson GL. Immunochemical localization of heparanase in mouse and human melanoma[J]. Int J Cancer, 1994,(56):286
  • 8[17]Hoogewerf AJ, Leone JW, Reardon IM, et al. CXC chemokines connective tissue activating peptide-Ⅲ and neutrophil activating peptide-2 are heparin/heparan sulfate-degrading enzymes[J]. J Biol Chem, 1995, 270(7):3268
  • 9[18]Sewell RF, Brenchley PE, Mallick NP. Human mononnclear cells contain an endoglycosidase specific for heparan sulphate glycosaminoglycan demonstrable with the use of a specific solid-phase metabolically radiolabelled substrate[J]. Biochem J, 1989, 264(3):777
  • 10[19]Freeman C, Parish CR. A rapid quantitative assay for the detection of mammalian heparanase activity[J]. Biochem J, 1997, 325):229

共引文献3

生物技术通讯
2005年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部