以Aβ为靶标治疗阿尔茨海默病的研究进展

Advances of β-amyloid peptide as a Therapeutic Target in Alzheimer's Disease

阿尔茨海默病(AD)是以认知功能障碍和记忆损害为特征的神经退行性疾病,是老年人中常见的一种痴呆症。β-淀粉样蛋白(Aβ)的沉积被认为是阿尔茨海默病发病的重要因素,它所形成的老年斑是该病的主要病理学特征。因此,以β-淀粉样蛋白为靶标可能是治疗阿尔茨海默病的有效方法,也是目前的研究热点。本文重点综述了近年以Aβ为靶标治疗AD的研究进展。

Alzheimer's disease (AD) is the most prevalent cause of dementia and memory loss among the elderly. It is characterized in part by the deposition of β-amyloid peptide in compact Aβ plaque formation. These structures can induce an innate immune response in the brain, which triggers progressive in ammation, neuronal loss, and further cognitive decline. This review focus on the β-amyloid peptide as a therapeutic target in Alzheimer's disease.