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产前束缚应激刺激对子代大鼠脑海马中Bax、Bcl-2、Fas和FasL表达的影响 被引量:6

Effect of prenatal restraint stress on the expressions of Bax, Bcl-2, Fas and FasL in hippocampus of the offspring
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摘要 目的确定产前束缚应激刺激对子代大鼠脑海马中Bax、Bcl-2、Fas和FasL表达的影响.方法在母鼠怀孕的13~19 d,每天进行3次束缚应激,每次45 min.于雌、雄仔鼠1月龄时对脑组织切片应用免疫组化方法检测海马中Bax、Bcl-2、Fas和FasL的表达.结果应激组Bax的表达强于对照组(P<0.05),Bcl-2的表达弱于对照组(P<0.05),Fas和FasL的表达两组间没有差异(P>0.05).结论产前束缚应激刺激可使子代大鼠脑海马神经元中Bax表达上调,Bcl-2表达下调,对Fas和FasL的表达没有影响. Objective To study the effect of chronic restraint stress on the expressions of Bax, Bcl-2, Fas and FasL in hippocampus of the offsprings during the pregnancy. Methods Restraint stress was performed three times each day of pregnant women from day 13 to day 19 (each time for 45min). After delivery, the expression of Bax, Bcl-2, Fas and FasL in hippocampus of one-month-old female and male rats were respectively examined by immunohistochemical method. Results Compared with the control group, the expression level of Bax in stressed group is higher (P<0.05), and the expression level of Bcl-2 is lower (P<0.05); there is no significant difference in the expression of Fas and FasL(P> 0.05). Conclusion Restraint stress during the pregnancy can upgrade the expression of Bax and degrade the expression of Bcl-2 of the offsprings; no effect was found on the expressions of Fas and FasL of the offsprings.
出处 《西安交通大学学报(医学版)》 CAS CSCD 北大核心 2005年第1期26-28,47,共4页 Journal of Xi’an Jiaotong University(Medical Sciences)
基金 西安交通大学重点培植项目
关键词 产前应激 海马 BAX Bcl-2 Fas FASL prenatal stress hippocampus Bax Bcl-2 Fas FasL
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参考文献10

  • 1席刚明,汪华侨,唐廷勇,周丽华,阮奕文,范华燕,叶天雄.胚胎时期大鼠海马结构的发育[J].四川解剖学杂志,1999,7(1):16-21. 被引量:5
  • 2Lupien SJ, de Leon M, de Santi S, et al. Cortisol levels during human aging predict hippocampal atrophy and memory deficits [J]. Nature Neurosci, 1998, 1:69-71.
  • 3Sapolsky R, Krey L, McEwen. Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging [J]. J Neurosci, 1985,8(5): 1222-1227.
  • 4Barbazanges A, Piazza PV, Le Moal M, et al. Maternal glucocorticoid secretion mediates long-term effects of prenatal stress [J]. J Neurosci, 1996, 16(12):3943-3949.
  • 5Takahashi LK. Prenatal stress: Consequences of glucocorticoids on hippocampal development and function [J]. Iht J Devl Neuroscience, 1998,16(3-4) :199-207.
  • 6Gould E, Woolley CS, McEwen BS. The hrppocampal formation: morphological changes induced by thyroid, gonadal and adrenal hormones [J]. Psychoneuroendocrinology, 1991,16 (1-3):67-84.
  • 7Schumacher M, Robel P, Baulieu EE. Development and regeneration of the nervous system: a role for neurosteroids [J]. Dev Neurosci, 1996, 18(1-2):6-21.
  • 8Green DR. Apoptotic pathways: The road to ruin [J]. Cell,1998, 94(6):695-698.
  • 9Bieganowska KD, Ausubel LJ, Modabber Y, et al. Direct ex vivo analysis of activated, Fas-sensitive autoreactive T cells in human autoimmune disease [J]. J Exp Med, 1985,185(9):1585-1594.
  • 10Giordano C, Stassi G, De Maria R, et al. Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis [J]. Science, 1997, 275(5302): 960- 963.

二级参考文献2

  • 1S. A. Bayer Phd. Changes in the total number of dentate granule cells in juvenile and adult rats: A correlated volumetric and 3H-thymidine autoradiographic study[J] 1982,Experimental Brain Research(3):315~323
  • 2姚志彬.海马——研究神经科学的理想模型[J].广东解剖学通报,1989,11(1):17-21. 被引量:23

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