用N-LOK改性淀粉包合独活寄生颗粒挥发油研究

Inclusion complex of the volatile oil from Duhuo Jisheng Granule

目的:比较N LOK与β CD对独活寄生颗粒(独活、细辛、防风等)挥发油的包合能力与工艺过程。方法:用胶体磨 法与搅拌法包合,并经差热、GC/MS分析。结果:N LOK对挥发油的包合率约为β CD的2倍:包合前后挥发油主要成分 基本一致。结论:N LOK挥发油包合物含油率高,可直接喷雾干燥,β CD挥发油包合物含油率低,需要冷藏及低温干燥。 采用N LOK包合挥发油更接近中成药工业规模生产实际。

AIM: To compare N-LOK with β-CD on inclusion ability for the volatile oil from Duhuo Jisheng Granula (Radix Angelicae, Pubescentis, Herba Asari, Radix Saposhni-koviae, etc). and its process. METHODS: Colloidal mill and mixer were adopted, and analysis was on use of DSC and GC/MS. RESULTS: N-LOK inclusion complex included oil ratio was twice as large as the β-CD, GC/MS analysis showed that the main components of volatile oil before and after being covered had no significant difference. CONCLUSION: N-LOK inclusion complex included oil ratio was far higher than the β-CD. N-LOK inclusion complex could spray to dry directly, but β-CD inclusion complex needed refrigeration and low temperature were necessary. The method of covered with N-LOK is suitable for mass production in the traditional Chinese patent medicine in the size of manufacture.