家兔实验性上颌窦炎黏膜病理及超微结构变化

Mucosal pathologic and ultrastructure changes of experimental maxillary sinusitis in rabbits

目的:探讨家兔实验性上颌窦炎黏膜随病程的迁延而出现的常规和超微病理变化,并根据病理变化初步估计急、慢性上颌窦炎的时间分界。方法:将制成上颌窦炎模型的30只新西兰大白兔按制模时间的长短分成不同组别,分别观察不同时间上颌窦黏膜的病理和超微结构变化。结果:制模3周内以急性炎症表现为主,3周后以慢性炎症表现为主。随病程迁延上皮层纤毛脱落增加、杯状细胞增生、鳞状上皮组织转化、上皮坏死,固有层腺体组织转化、减少、纤维化。结论:上颌窦炎黏膜的病理变化随病程延长而加重.急、慢性上颌窦炎以制模后3周为界。

Objective:To investigate mucosal pathologic and ultrastructure changes relate to experimental maxillary sinusitis process in rabbits.The demarcation of acute and chronic maxillary sinusitis will be determined according to pathologic effects.Method:Thirty New Zealand white rabbits have been induced sinusitis will be divided into different groups according to the time of process.The pathologic changes are observed by microscope,scanning electric microscope and transmission electric microscope.Result:Within 3 weeks to induce infection the inflammation mainly show in acute style while after 3 weeks the main manifestation are chronic changes.In epithelium layer cilia shedding increased,the number of goblet cell added,squamous epithelium metaplasia and epithelia necrosis were observed during inflammatory process.In lamina propria glands metaplasia and decreased,the fibrosis is densed.Conclusion:The pathologic changes of maxillary mucosa are related to process.The borderline of acute and chronic experimental maxillary sinusitis is 3 weeks.