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皮肤鳞状细胞癌中FHIT蛋白的检测及其临床意义 被引量：7

Detection of Fragile Histindine Triad Protein in Cutis Squamous Cell Carcinoma and Its Clinical Significance
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摘要 目的探讨皮肤鳞状细胞癌(SCC)组织中脆性组氨酸三联体(FHIT)蛋白的表达及临床意义。方法应用免疫组化SP法,检测32例SCC及12例正常皮肤组织标本中FHIT蛋白的表达。结果SCC及正常皮肤组织中FHIT蛋白的阳性表达率分别为43.75%(14/32),100%(12/12),两者差异有显著性意义(P<0.001)。淋巴结转移组和无淋巴结转移组FHIT的阳性表达率分别为30.4%(7/23)和77.78%(7/9),两组差异有显著性意义(P<0.05)。结论FHIT在SCC的发生、发展中起重要作用,检测SCC中FHIT蛋白的表达有助于了解其发生、发展及转移的机制,为临床治疗提供理论依据。 Objective To investigate the level of fragile histindine triad protein(FHIT) in cutis squamous cell carcinoma. Methods The level of FHIT were detected by SP immunohistochemical staining technique in 32 paraffin embedded specimens of SCC and 12 non-cancerous normal cutis tissue.Results The positive rate of FHIT in SCC and normal cutis tissue were 43.75%(14/32) and 100%(12/12)(P<0.001),respectively. In lymph node metastatic group,the positive rate of FHIT were 30.4%(7/23),and non-metastatic was 77.78%(7/9).There were significant difference between the two groups(P<0.05). Conclusion FHIT might play an important role in the carcinogenesis and progress of SCC.Studying the level of FHIT might be helpful to predict the pathogenesis and metastatic potential of SCC and to provide theoretic basis for clinical therapy.
作者 田中伟 冯捷 宋向凤 马慧群 彭振辉
机构地区 西安交通大学第二医院皮肤科 新乡医学院基础医学院
出处 《中国皮肤性病学杂志》 CAS 北大核心 2005年第2期68-70,共3页 The Chinese Journal of Dermatovenereology
关键词 鳞状细胞癌 胞性组氨酸三联体 Squamous cell carcinoma Fragile histindine triad
分类号 R739.5 [医药卫生—肿瘤]
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参考文献10

  • 1田中伟,宋向凤,彭振辉.人皮肤T细胞淋巴瘤系Hut-78细胞FHIT基因缺失的研究[J].中国皮肤性病学杂志,2003,17(5):289-290. 被引量：6
  • 2殷德涛,董明敏,卢秀波.头颈部鳞状细胞癌组织中脆性组氨酸三联体基因的表达[J].郑州大学学报（医学版）,2003,38(4):548-550. 被引量：12
  • 3Ohta M,Inoue H,Cotticclli MG,et al.The FHIT gene,spanning the chromome 3p14.2 fragile site and renal carcinoma associated t(3;8) breakpoint,is abnormal in digestive tract cancers[J].Cell,1996,84:587-597.
  • 4Tai SK,Lee JI,Ang KK,et al.Loss of Fhit Expression in Head and Neck Squamous Cell Carcinoma and Its Potential Clinical Implication[J].Clin Cancer Res,2004,15;10(16):5554-5557.
  • 5Butle D,Collins C,Mabruk M,et al.Loss of Fhit expression as a potential marker of malignant progression in preinvasive squamous cervical cancer[J].Gynecol Oncol,2002,86(2):144-149.
  • 6Pavelic K,Krizanac S,Cacev T,et al.Aberration of FHIT gene is associated with increased tumor proliferation and decreased apoptosis-clinical evidence in lung and head and neck carcinomas[J].Mol Med,2001,7(7):442-453.
  • 7Matthews CP,Shera K,Kiviat N,et al.Expression of truncated FHIT transcripts in cervical cancers and in normal human cells[J].Oncogene,2001,20(34):4665.
  • 8Greenspan DL,Connolly DC,Wu R,et al.Loss of FHIT expression in cervical carcinoma cell lines and primary tumors[J].Cancer Res,1997,57:4692-4698.
  • 9Hallas C,Albitar M,Letofsky J,et al.Loss of FHIT expression in acute lymphoblastic leukemia[J].Clinical Cancer Res,1999,5:2409-2414.
  • 10Ji L,Fang B,Yen N,et al.Induction of apoptosis and inhibition of tumor igenicty and tumor growth by adenovirus vector mediated fragile histidine triad(FHIT) gene over expression[J].Cancer Res,1999,59(14):3333-3338.

二级参考文献15

  • 1Ohta M, Inoue H, Cotticelli MG, et al. The FHIT gene,spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t ( 3 ; 8 ) breakpoint, is abnormal in digestive tract cancers. Cell, 1996,84(4) :587.
  • 2Yang Q, Nakamura M, Nakamura Y, et al. Two-Hit Inactivation of FHIT by loss of heterozygosity and hypermethylation in breast cancer. Clin Cancer Res,2002,8(9) :2890.
  • 3Matthews CP, Shera K, Kiviat N, et al. Expression of truncated FHIT transcripts in cervical cancers and in normal human cells. Oncogene,2001,20(34) :4665.
  • 4Deng YF, Tian F, Lu YD, et al. Mutation and abnormal expression of the fragile histidine triad gene in nasopharyngeal carcinoma. Laryngoscope ,2001,111(9) : 1589.
  • 5Ishii H, Dumon KR, Vecchione A, et al. Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells. Cancer Res,2001,61(4):1578.
  • 6Kannan K, Munirajan AK, Bhuvarahamurthy V, et al. FHIT gene mutations and single nucleotide polymorphism in Indian oral and cervical squamous cell carcinomas. Oral Oncol,2000,36(2) :189.
  • 7Ji L, Fang B, Yen N, et al. Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression. Cancer Res,1999,59(14) :3333.
  • 8Gotte K, Hadaczek P, Coy JF, et al. Fhit expression is absent or reduced in a subset of primary head and neck cancer. Anticancer Res,2000,20(2A) : 1057.
  • 9Greenspan DL, Connolly DC,Wu R, et al. Loss of FHIT expression in cervical carcinoma cell lines and primary tumors[J]. Cancer Res, 1997,57: 4692 - 4698.
  • 10Mao L, Fan YH, Lotan R, et al. Suppressor gene in head and neck cancer cell lines[J]. Cancer Res, 1996,56:5128- 5131.

共引文献15

同被引文献34

引证文献7

二级引证文献8

中国皮肤性病学杂志
2005年 第2期

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