高血压对良性前列腺增生细胞增殖与凋亡的影响

Effect of Hypertension on Cell Proliferation and Apoptosis in Benign Prostatic Hyperplasia

目的:探讨高血压对良性前列腺增生(BPH)细胞增殖与凋亡的影响。 方法:分别采用Ki 67免疫组织化 学染色及核酸末端原位标记技术(TUNEL)对40例单纯BPH和40例BPH合并高血压患者前列腺组织的细胞增殖 指数(proliferativeindex,PI)与凋亡指数(apoptoticindex,AI)进行检测。 结果:在单纯BPH以及BPH合并高血 压组,前列腺上皮和间质细胞的PI均大于AI(P<0.05),且PI与前列腺体积呈正相关(P<0.05)。与单纯BPH组 比较,BPH合并高血压组前列腺上皮和间质细胞的PI明显增高(P<0.05)。在BPH合并高血压组,高血压病程的 长短与前列腺上皮和间质细胞的PI呈正相关(P<0.05)。 结论:高血压尤其是长期高血压状态可促进前列腺 上皮和间质细胞的增殖,进而导致前列腺体积增大。

Objective: To evaluate the effect of hypertension on cell proliferation and apoptosis in benign prostatic hyperplasia (BPH). Methods: The techniques of immunohistochemistry and terminal deoxynucleotidyl transterase-mediated dUTP biotin nick end labeling(TUNEL) were used to detect the proliferative index (PI) and apoptotic index (AI) in both epithelium and stroma of simple BPH (40 cases) and BPH with hypertension (40 cases), respectively. Results: In both the groups of simple BPH and BPH with hypertension, the value of PI was significantly higher than that of AI in epithelium and stroma (P< 0.05), and PI was closely related to the prostate volume (P< 0.05). As compared with the simple BPH group, PI was significantly increased in epithelium and stroma in the group of BPH with hypertension(P< 0.05), in which the disease history of hypertension was positively associated with PI in epithelium and stroma (P< 0.05). Conclusion: Hypertension, particularly persistent hypertension state, may enhance cell proliferation in both epithelium and stroma of BPH, and consequently lead to the enlargement of the prostate.