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Klinefelter综合征患者卵细胞胞质内单精子注射治疗和子代患染色体病的风险 被引量：2

Intracytoplasmic Sperm Injection for Klinefelter Patients and the Risk of Chromosome Anomaly in the Patients' Offspring
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摘要 Klinefelter综合征患者以47,XXY核型,睾丸精曲小管发育不良,无精子症和不育为特征。但极少数患者仍有 局部生精灶和少量精子发生。近年来由于辅助生育技术的发展,Klinefelter综合征患者经睾丸活检取精子和卵细胞 胞质内单精子注射(ICSI)治疗后已有30多个健康胎儿出生,但也有1例报告妊娠胚胎的核型为47,XXY而选择流 产。本文对近年来Klinefelter综合征患者的ICSI治疗的现状及子代患染色体病风险进行综述。 Patients with Klinefelter's syndrome are generally characterized by a 47,XXY karyotype, seminiferous tubule dysgenesis, azoospermia and infertility. However, focal spermatogenesis and severe oligozoospermia have been found in a few cases of 47, XXY, too. With the recent development in assisted reproductive technologies, the recovered spermatozoa by testicular biopsy from Klinefelter patients have been used for intracytoplasmic sperm injection(ICSI) and over 30 healthy neonates have been born. The conception of one 47, XXY fetus was found and then underwent abortion. This review focuses on the ICSI treatment of infertility in Klinefelter patients and the risk of chromosome anomaly in the offspring of these patients.
作者 周秦 崔英霞
机构地区 南京军区南京总医院生殖遗传研究室
出处 《中华男科学杂志》 CAS CSCD 2005年第2期149-151,共3页 National Journal of Andrology
关键词 KLINEFELTER综合征 卵细胞胞质内单精子注射 染色体病 子代 风险 Klinefelter's syndrome intracytoplasmic sperm injection chromosome anomaly offspring risk
分类号 R698.2 [医药卫生—泌尿科学]
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参考文献16

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共引文献33

同被引文献15

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中华男科学杂志
2005年 第2期

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