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急性白血病分子治疗新靶标:信号转导途径的“单击”或“多击”策略 被引量:3

New targets for molecular therapy of acute leukemia: a "single-hit" or "multiple-hit" strategy against signaling pathway
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作者 张广森
出处 《中华医学杂志》 CAS CSCD 北大核心 2005年第7期437-438,共2页 National Medical Journal of China
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参考文献4

  • 1Lancet JE, Gojo I, Gotlib J,et al. Tipifarnib(ZARNESTRA) in previously untreated poor-risk AML and MDS: interim results of a phase 2 trial. Blood, 2003,102:176a.
  • 2Smith DB, Levis M, Beran M, et al. Single-agent CEP701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia. Blood, 2004,103:3669-3676.
  • 3Stone RM, Deangelo DJ, Klimek V, et al. Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412. Blood, 2005,105:54-60.
  • 4Brown P, Lavis M, Shurtleff S, et al. FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression. Blood, 2005,105:812-820.

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