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加替沙星治疗老年患者肺部感染疗效观察 被引量:7

Gatifloxacin in Treatment of Pulmonary Infections of Elder People
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摘要 目的 评价加替沙星治疗老年患者肺部感染的疗效和安全性。方法 加替沙星治疗老年患者肺部感染 32例,给予加替沙星400mg /d,观察临床症状及实验室检查、细菌学检查,评价临床疗效及细菌学疗效。结果 临床总有效率90 62%,细菌清除率为91 66%,不良反应少,且能耐受。结论 加替沙星治疗老年患者肺部感染疗效佳,使用安全。 OBJECTIVE To evaluate the efficacy and safety of gatifloxacin in treatment of pulmonary infections of elder people. METHODS Thirty two elder patients with pulmonary infection were treated with gatifloxacin (400mg, qd). After that to observe clinical symptoms and laboratory changes, to do bacterial inspections and to evaluate clinical efficacy in treatment of bacterial infections. RESULTS Clinical efficacy rate was 90 62%, microbiologic eradication rate was 91 66%, The incidence of adverse reaction was quite low. CONCLUSIONS It is concluded that gatifloxacin has an excellent clinical efficacy and good safety in treating elder patients with pulmonary infections.
出处 《中华医院感染学杂志》 CAS CSCD 北大核心 2005年第2期186-187,共2页 Chinese Journal of Nosocomiology
关键词 加替沙星 老年人 肺部感染 Gatifloxacin Elderly Pulmonary infection
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  • 1[1]Lacreta FP, Kaul S, Kollia GD, et al. Interchangeability of 400mg intravenous and oral gatifloxacin in healthy adults[J]. Pharmacotherapy, 2000, 20(6 pt 2): 59.
  • 2[2]Perry CM, Barman Balfour JA, Lamb HM.Gatifloxacin[J]. Drugs, 1999, 58(4) :683、697.
  • 3[3]Lober S,Ziege S, Rau M,et al. Pharmacokinetics of gatifloxacin and interaction with an antacid containing aluminum and magnesium[J ]. Antimicrob Agents Chemother, 1999, 43(5): 1 067.
  • 4[4]Lutsar I,Friedland IR,Wubbel L, et al. Pharmacodynamics of gatifloxacin in cerebrospinal fluid in experimental cephalosporin-resistant pneumococcal meningitis[J]. Antimicrob Agents Chemother, 1998, 42 (10):2 650.
  • 5[5]Gajjar DA, Lacreta FP, Uderman HD, et al. A dose-escalation study of the safety, tolerability, and pharmacokinetics of intravenous gatifloxacin in healthy adult men[J]. Pharmacotherapy, 2000, 20(6 Pt 2): 49.
  • 6[6]Lacreta FP, Kollia GD, Duncan G, et al. Age and gender effects on the pharmacokinetics of gatifloxacin[J ]. Pharmacotherapy, 2000, 20(6 Pt 2) :67.
  • 7[7]Grasela DM, Lacreta FP, Kollia GD, et al. Open-label,nonrandomized study of the effects of gatifloxacin on the pharmacokinetics of midazolam in healthy male volunteers[J ]. Pharmacotherapy, 2000, 20(3): 330.
  • 8[8]Lu T,Zhao X,Drlica K.Gatifloxacin activity against quinolone-resistant gyrase: allele-specific enhancement of bacteriostatic and bactericidal activities by the C-8methoxy group[J ]. Antimicrob Agents Chemother, 1999,43(12):2 969.
  • 9[9]Fukuda H, Hiramatsu K.Primary targets of fluoroquinolones in streptococcus pneumoniae[J]. Antimicrob Agents Chemother, 1999, 43(2): 410.
  • 10[10]Yamamoto T, Kusajima H, Hosaka M, et al. Uptake and intracellular activity of AM- 1155 in phagocytic cells[J].Antimicrob Agents Chemother, 1996, 40(12): 2 756.

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