sICAM-1和sVCAM-1与乙肝病毒标志物关系的研究

Study on Relation of Soluable Vascular Cell Adhesion Molecule-1and Soluable Intercelluar Adhesion Molecule-1 to Hepatitis-B Virus Marker

目的探讨可溶性血管内皮细胞间黏附分子1(sVCAM -1)和可溶性细胞间黏附分子1(sICAM -1)的水平与乙肝病毒标志物之间的关系。方法用ELISA法测定乙肝病毒标志物、sVCAM -1、sICAM -1,用PCR法定量测定HBV-DNA的含量。结果HBVM阳性者 ,除HBsAb阳性者外 ,其血清sV CAM -1、sICAM -1水平较全阴性者均有较明显的升高 ,但升高的各组间无明显差异 ;sICAM -1与ALT呈正相关 (r=0.662) ,与HBA -DNA呈负相关(r= -0.498) ;sVCAM -1与ALT、HBV -DNA的相关系数r分别为0.191、-0.027。结论1、乙肝病毒感染者血清sVCAM -1、sICAM -1有明显的升高 ,各组间无明显差异。2、sICAM -1的水平可以反应肝脏的损害程度和HBV-DNA的复制情况。

Objective To study the relation of soluable vascular cell adhesion molecule-1(sVCAM-1)and soluable intercelluar adhesion molecule-1(sICAM-1)with hepatitis-B virus marker(HBVM).Methods HBVM and the serum levels of sICAM-1,sVCAM-1were measured with ELISA method in52cases od HBVM positive patients and23cases of healthy subjects(13cases only HBsAG positive,10case all HBVM negetive),HBVM-DNA was quantitatively analyzed with PCR.Results Except the only HbsAb positive group,the serum levels of sVCAM-1,sICAM-1in patients of HBVM positive group are obviously higher than those in healthy group;but among the patients there is no obvious difference;sICAM-1is positively related to ALT(r=0.662),SICAM-1is negatively related to HBV-DNA(r=-0.498);The related coefficient of sVCAM-1with ALTand HBV-DNA is0.191and-0.027.Conclusions Except the only HbsAb positive group,the serum level of sVˉCAM-1,sICAM-1is obviously higher in other HBVMpositive groups;the sICAM-1level can reflect the damˉage degree of liver and the replication state of HBV-DNA.