新生儿缺氧缺血性脑病血阴离子间隙分析

The analysis of anion gap in neonates with hypoxic ischemic encephalopathy

目的 探讨新生儿缺氧缺血性脑病 (HIE)患儿血阴离子间隙 (AG)的变化及其临床意义。方法 测定 15 0例HIE新生儿和 70例正常新生儿的血气及血清电解质 ,计算AG值及进行对比观察。结果 HIE患儿 139例存在酸碱紊乱 ,高AG代谢性酸中毒 91例 ,HIE新生儿组AG值显著高于正常对照组 (P <0 0 1) ,且以重度HIE组更甚。结论 HIE患儿常存在酸碱紊乱 ,对HIE患儿应密切监测血气及血清电解质变化 ,并计算AG值 ,及早发现和尽快纠正酸碱及电解质紊乱 。

Objective To investigate the changes and clinical significance of anion gap (AG) in neonates with hypoxic ischemic encephalopathy (HIE).Methods The blood gas analysis and serum electrolyte were tested in 150 cases of neonates with HIE and 70 cases of normal neonates,count AG value,paired observation was carried out.Results The 139 cases of neonates with HIE has acid-base disorders,91 cases of them were metabolic acidosis with high AG value,the AG value in the HIE group were significantly higher than that in the normal control group (P<0.01),especially in neonates with severe HIE.Conclusion When the neonates had HIE,there often exists acid-base disorders.So we should monitor closely the changes of the blood gas and serum electrolyte,count AG value,discover promptly to correct acid-base and electrolyte disorders,and it will raise the cure rate of neonates with HIE.