硒对镉致大鼠肺巨噬细胞吞噬和Fc受体表达抑制的保护作用

Selenium protection against cadmium induced inhibition of phagocytosis and Fc receptor of rat alveolar macrophages

用体外实验的方法,在观察镉化合物致大鼠肺巨噬细胞吞噬功能和Fc受体表达功能抑制的基础上,研究了硒对镉毒性的拮抗作用。结果表明,氯化偏的毒性是氧化镉毒性的10倍。硒可拮抗氯化镉致肺巨噬细胞的抑制效应。同时还对氯化镉与氧化镉的毒性差别和硒的保护作用进行了探讨。

Cadmium chloride and cadmium oxide induced inhibition of phagocy- tosis and Fc receptor expression of rat alveolar macrophages in vitro were observed.The results showed that the toxicity of cadmium chloride was 10 times higher than that of cadmium oxide. Selenium could pro- tect against cadmium chloride induced inhibition of phagocytosis and Fe receptor expression. The difference of cadmium chloride and cadmium ox- ide in toxicity and the phenomena of selenium protection was discussed.