香烟烟雾凝结物和香烟滤嘴截留物对人外周血淋巴细胞SCE的影响

The effect of cigarette smoke condensate and cigarette smoke filter-absorbing-content on SCE of human peripheral blood lymphocytes

用香烟烟雾凝结物(CSC)诱导离体培养的人外周血淋巴细胞姐妹染色单体交换(SCE),所用香烟牌号不同SCE率亦不同,低焦油含量的香烟并不能降低其诱导作用;同一种材料的滤嘴对不同牌号香烟的滤过效率不同,蝶桥牌香烟有无滤嘴对SCE的影响没有显著差异;本研究首次发现香烟滤嘴截留物(CSFAC)虽能提高SCE频率,但通过滤嘴后的CSC仍有很强的诱导SCE作用。

Cigarette smoke condensate(CSC)derived from a low-tar and a med ium-tar cigarette, and from several types of cigarette with filters was tested for its effect on SCE rates of human peripheral blood lymphocytes (PBL).Examination revealed no correspondence between the increase of SCE rates and the tar content of the cigarettes.The effect of the filters of different types was found to be associated with the brands of cigarettes and some filters have little effect in a given brand.The incidence of SCEs was highly significant in the experimental group with added cigarette smoke filter absorbing-content(CSFAC)than in control.