期刊文献+

115例重症肌无力患者胸腺切除手术的麻醉管理 被引量:6

下载PDF
导出
摘要 目的 探讨重症肌无力(MG)患者胸腺切除手术的麻醉处理方法和分析术后需要呼吸支持的原因。方法 115例MG患者经胸骨正中劈开胸腺切除手术,MG分型:Ⅰ型 12 例,Ⅱa型 20例,Ⅱb型68例,Ⅲ型10例,Ⅳ型5例。术前口服平时用量的溴吡斯的明;诱导用丙泊酚、芬太尼和琥珀胆碱;麻醉维持用氧气、氧化亚氮和异氟醚。术中不用非去极化的肌松药。拔管指征:患者完全清醒,抬头坚持5s,潮气量大于10 ml/kg, 吸气负压峰值大于-20 cmH2O。术后 6 h内开始口服小剂量的溴吡斯的明。根据术后是否需要呼吸支持分成两组:术后立即拔管组和术后延迟拔管组。结果 101例在手术室内成功拔管,拔管率为87 .8%;14例术后需呼吸支持6 h至7 d,术后延迟拔管率为12. 2%;术后需要带气管导管和呼吸支持的患者随MG的临床分级增加而增高。结论 MG患者行胸腺切除术用丙泊酚、芬太尼和琥珀胆碱麻醉诱导,吸入氧气、氧化亚氮和异氟醚维持,是一种安全的麻醉方法;MG患者术后需要呼吸支持的发生率随MG的临床分级增加而增高。
出处 《临床麻醉学杂志》 CAS CSCD 2005年第2期105-107,共3页 Journal of Clinical Anesthesiology
  • 相关文献

参考文献7

  • 1Baraka A. Anaesthesia and myasthenia gravis. Can J Anaesth,1992,39:476- 486.
  • 2Chevalley C, Spiliopoulos A, de Perrot M, et al. Perioperative medical management and outcome following thymectomy for myasthenia gravis. Can J Anaesth,2001,48:446-451.
  • 3Gracey DR, Divertie MB, Howard FM Jr, et al. Postoperative respiratory care after transsternal thymectomy in myasthenia gra vis. A 3-year ex perience in 53 patients. Chest,1984,86:67-71.
  • 4Naguib M,ei Dawlatly AA, Ashour M, et al. Multivariate determinants of the need for postoperative ventilation in myasthenia gravis. Can J Anaesth, 1996,43 : 1006-1013.
  • 5Eisenkraft JB, Book WJ, Mann SM, et al. Resistance to succinylcholine in myasthenia gravis: a dose response study. Anesthesiology, 1988,69 : 760-763.
  • 6Della Rocca G, Coccia C, Diana L, et al. Propofol or sevoflurane anesthesia without muscle relaxants allow the early extubation of mvasthenic patients. Can J Anaesth,2003,50:547-552.
  • 7Mann R, Blobner M, Jelen Esselborn S, et al. Preanesthetic train-of-four fade predicts the atracurium requirement of myasthenia gravis patients. Anesthesiology, 2000,93 :346- 350.

同被引文献51

  • 1张润希,李保华,徐金枝.重症肌无力患者血乙酰胆碱酯酶活性测定及其临床意义[J].实用医学杂志,2005,21(1):43-44. 被引量:7
  • 2易杰,郝绒绒,罗爱伦,黄宇光.无肌松药下瑞芬太尼复合异丙酚靶控输注诱导病人气管插管的可行性[J].中华麻醉学杂志,2006,26(4):293-295. 被引量:23
  • 3鲁卫华,金孝岠,柳兆芳,戴泽平.重症肌无力病人胸腺切除术后罗哌卡因混合曲马多硬膜外镇痛的效果[J].中华麻醉学杂志,2006,26(11):1042-1043. 被引量:2
  • 4徐春敏,朱乐亭,韩容.舒芬太尼注射液[J].中国新药杂志,2007,16(2):174-176. 被引量:31
  • 5Chevalley C,Spiliopoulos A,de Perrot M,et al.Perioperative medical management and outcome following thymectomy for myasthenia gravis.Can J Anaesth,2001,48(5):446-451.
  • 6Pandin PC,Cantraine F,Ewalenko P,et al.Predictive accuracy of target-controlled propofol and sufentanil coinfusion in long-lasting surgery.Anesthesiology,2000,93 (3):653-661.
  • 7Frolich MA,Dennis DM,Shuster JA,et al.Precision and bias of target controlled propofol infusion for sedation.Br J Anaesth,2005,94(4):434-437.
  • 8Mertens MJ,Olofsen E,Engbers FH,et al.Propofol reduces perioperative remifentanil requirements in a synergistic manner:response surface modeling of perioperative remifentanil-propofol interactions.Anesthesiology,2003,99 (2):347-349.
  • 9Delia Rocca G, Coccia C, Diana L, et al. Propofol or sevolflurane anesthesia without muscle relaxants allow the early extubation of myasthenic patients [J]. Can J Anaesth,2003,50 (6) :547-552.
  • 10Lentschener C, Ghimouz A, Bonnichon P, et al. Remifentanil- propofol vs.sufentanil-propofol:optimal combination in clincla anesthesia [J].Acta Anesthesiologica Scandinavica,2003,47 ( 1 ) : 84-89.

引证文献6

二级引证文献27

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部