山莨菪碱对急性弥散性血管内凝血防治作用的实验研究

INVESTIGATION OF THE PREVENTIVE AND CURATIVE EFFECTS OF ANISODAMIN ON ACUTE DIC

对山莨菪碱(654-2)防治急性弥散性血管内凝血(DIC)的作用进行了实验研究。研究发现654-2防治组家兔肠系膜微循环流速极少减慢,细胞聚集极轻,微血管内初期可出现微血栓,但能很快减少并完全消失;凝血酶原时间(PT)正常,白陶土部分凝血活酶时间(KPTT)仅轻度延长(5min,P<0.05;60min,P<0.01),纤维蛋白原消耗亦较轻(P>0.05));病理检查发现肺、肾毛细血管及细动脉内极少有血栓形成。说明654-2有较明显的抗凝、抗血栓、改善微循环作用,从而达到防治 DIC 的目的。

In this paper,the preventive and curative action of anisodamin on acute DIC was observed. It showed that the slowing down of blood stream and the aggregation of erythrocytes in the rabbit mesentary microcirculation of anisodamin group were much less than those of DIC group.Mi- crothrombi appeared in the microvessels during the initial stage,but reduced gradually and then disappeared.PT was in normal range(P<0.01).KPTT was prolonged slightly(5min,P< 0.05;60min,P<0.01),and fibrinogen was consumed lightly too(but P>0.05)in this group. Occasionally,only a few microthrombin appeared in some capillaries of the lung in anisodamin group.It was proved that anisodamin can prevent and cure acute DIC through its action of antico- agulation,antithrombus and the improvement of microcirculation.