对病毒性肝炎及无症状HBsAg携带者血清甲胎蛋白的检测

DETERMINATION OF SERUM ALPHA—FETOPROTEIN IN PATIENTS WITH VIRAL HEPATITIS AND ASYMPT—OMATIC HBsAg CARRIER

对462例次病毒性肝炎(VH)及无症状 HBsAg 携带者(ASC)的血清甲胎蛋白(AFP)进行了定量检测,结果大部分急性肝炎(AH)及慢性活动性肝炎(CAH)呈现轻度增高,且在 AH 急性期高于恢复期,在 CAH 活动期高于好转期(P<0.01),AFP 明显增高的4例 CAH 中有1例最终发展为犴细胞癌。而ASC 的 AFP 含量大多正常,在不同 HBsAg 滴度及乙型肝炎病毒(HBV)复制状态下差异均无显著性(P>0.05)。作者认为,对 VH 检测 AFP 定量可有助于了解肝细胞的病变程度及修复情况,对 AFP 明显增高的 VH 则应注意与肝癌作好鉴别诊断,并密切注意向肝癌发展的倾向。

Assay of serum Alpha—fetoprotein(AFP)was performed in 216 patients with viral hapatitis and 188 asymptom—atic HBsAg carrier(ASC).The result showed that in the acute stage of hepatitis,serum AFP was increased and then returned to normal level in the convalescent stage.High level of AFP (>300μg/L)was observed in font patients with CAH,one of them was found to develop into liver cancer after ten months.In ASC, the level of AFPwas mostly normal,and no difference in the diferent titer of HBsAg and condition of HBV reproduction.It is concluded,that necrosis and regeneration of the liv- er cells are the main causes of high AFP level,the attention should be paid to the pa- tients which has high level AFP with hepatitis,it is important in making diferential diag- nosis between viral hepatitis and hepatocellular carcinoma.