ICG、安替比林清除率作为中毒性肝损害指标的意义探讨

Evaluation for the usefulness of ICG and antipyrine clearance as the diagnostic indices for chemical-induced hepatotoxic damage

本文应用急性、亚急性四氯化碳(CCl_4)、三硝基甲苯(TNT)中毒性肝损害模型评估了吲哚氰绿(ICG)清除率、安替比林(Ap)清除率作为肝损害指标的意义。结果表明,ICG清除率可敏感地反映肝脏损害,而AP清除率则有缺陷。以肝脏为靶器官的亲肝种毒物迄今已超过600种,中毒性肝损害病例日益增多,如何运用一个合适的指标来筛检多毒物引起的肝损害越来越引起人们的重视。SGPT 是目前公认的能反映肝脏病变的指标,但它并不能灵敏地反映所有的肝损害。本文以CCl_4、TNT两种中毒性肝损害模型,应用模型化学物质ICG、AP,试图从中找出合适指标来反映多种毒物引起的肝损害。

ICG and antipyrine clearance in the acute and sub-acute intoxicated models of New Zeala-nd white rabbits by carbon tetrachloride and trinitrotoluene was evaluated in order to findout sensitive diagnostic indices for chemical-induced hepatotoxic damage. Results indicated thsICG clearance was a sensiti-ve index, rather than antipyrine clearance.