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免疫刺激复合物疫苗 被引量:1

Immune stimulating complex vaccines
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摘要 免疫刺激复合物疫苗 (ISCOM)与传统疫苗相比 ,不但疫苗抗原的需求量较少 ,而且能够增加抗体反应水平和持久性 ,还能产生强的细胞免疫反应 ,作为强的粘膜佐剂 ,在动物模型研究中发现同样适用于年老及新生动物。
作者 汪军远
机构地区 吉林大学药学院
出处 《国外医学(流行病学.传染病学分册)》 2005年第1期47-50,共4页 Epidemiology Lemology Foreign Medical Sciences
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  • 1Ennis FA, Cruz J, Jameson J, et al. Augmentation of human influenza A virus-specific cytotoxic T lymphocyte memory by influenza vaccine and adjuvanted carriers( ISCOM). Virology, 1999,259(2) :256-261.
  • 2Harrison GB, Shakes TR, Robinson CM, et al. Duration of immunity, efficacy and safety in sheep of a recombinat Taenia ovis vaccine formulated with saponin or selected adjuvants. Vet Immunol Immunopathol, 1999,70(3-4) : 161-172.
  • 3Hu KF, Chen M, Abusugra 1, et al. Different respiratory syncytial virus and quillaja saponin formulations induce murine peritoneal cells to express different proinflammatory cytokine profiles. FEMS Immunol Med Microbiol, 2001,31 (2) : 105-112.
  • 4van Pinxteren LA, Bruce MG, Campbell I, et al. Effect of oral rotavims/iscom vaccines on immune responses in gnotobiotic lambs. Vet lmmunol Immunopathol, 1999,71 ( 1 ) : 53-67.
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  • 6Morein B, Bengtsson KL. Immunonodulation by iscoms , immune stimualting complexes. Methods, 1999( 1 ), 19:94-102.
  • 7Regner M, Culley F, Fontanna Z, et al. Satety and efficacy of immuestimulating complex-based antigen delivery, system for neonatal immunization against respiratory. syncytial vires infection. Microbes Inffect, 2004,6(7) :666-675.
  • 8Grdic D, Smith R, Donachie A, et al. The mucosal adjuvant effects of cholera toxin and immune -stimualting complexes differ in their for requirement for IL-12, indicating different pathways of action. Eur J Immunol 1999,29(6) : 1774-1778.
  • 9Sjolander S,Drane D,Davis R,et al.Interanasal immunization with influenza-ISCOMS strong mucosal as well as systemic antibody and cytotoxic T-lymphocyte.Vaccine,2001,19(28.29):4072-4080.
  • 10Hu KF,Lovgren—Bengtsson K,Morein B,Immuostimulating complexes(ISCOMs)for nasal vaccinalion.Adv Drug Deliv Rev,2001,51(1-3):149-159.

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