6Tokunaga T, Yamamoto H, Suganuma T, et al. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium boris BCG. I. Isolation, physicochemical characterization, and antitumor activity [J]. JNCI, 1984,72:955 - 962.
7Yamamoto S, Yamamoto T, Tokunaga T, et 81. DNA from bacteria but not from vetebrates induces interferons, activates natural killer cells and inhibits tumor growth [J]. Microbiol Immunol, 1992, 36 (9) :983- 997.
8Sato Y, Roman M, Tighe H, et al. Immunostimulatory DNA sequences necessary for effeetlve intradermal gene immunization. Science, 1996,273 : 352 - 354.
9Daniela Verthelyi, Richard T. Kenney, Robert A. Seder, et al. CpG oligodeoxynucleotides as vaccine adjuvants in primates. The journal of immunology, 2002,1660- 1663.
10Daniela Verthelyi, ken J. Ishii, et al. Human peripheral blood cells differentially recognize and respond to two disinct CpG motifs[J] .J Immunol, 2001,16 : 2372 - 2377.
2Krieg A M, Yi A K, Matson S,et al.CpG motifs in bacterial DNA trigger direct B-cell activation [J]. Nature,1995,374:546.
3Sparwasser T, Koch E S, Vabuiias R M, et al. Bacteriaal DNA and immunostimulatory DNA: sequences dependent production of potentially harmful or useful cytokines [J].Eur J Immunol, 1998,28: 2045.
4Kuramoto E,Yano O,Kimura Y,et al.Oligonucleotide sequences required for natural killer cell activation [J].Jpn J Cancer Res.1992,83:1128.
5Lipford A M, Yi A K, Matson S, et al. Immunostimulatory DNA: sequence dependent production of potentially harmful or useful cytokines [J]. Eur J Immunol, 1997, 27:3420.
6Jones T R, Cbaldia N, Gramzinski R A, et al. Synthetic oligodeoxynucleotides containing CpG motifs enhance immunogenicity of a peptide malaria vaccine in Aotus monkeys[J]. Vaccine, 1999,17: 3065.
7Weiner G J, Liu H M, Woldridge J E, et al. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization [J]. Proc Natl Acad Sci USA, 1997,94:10833.
8Krieg A M. Mechanisma and applications of immune stimulatory CpG oligodeoxynucleotides [J]. Biochemica Biophysica Acta, 1999,1489:107.
9Moldoveanu Z, Homan L L, Huang W Q, et al. CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus [J]. Vaccine, 1998,16:1216.
10Yi A K , Krieg A M . Rapid induction of mitogen-activated protein kinases by immune stimulatory CpG DNA [J]. J Immunol,1998,161:4493.
