2003年广州地区常见病原菌耐药性调查

Surveillance of common pathogenic bacterial resistance in Guangzhou in 2003

目的 了解广州地区常见病原菌耐药情况,为临床合理用药提供依据。方法 采用纸片扩散法进行药敏试验,用WHONET5.1软件进行统计分析。结果 共收集病原菌2 047株,其中革兰阳性球菌697株,革兰阴性杆菌1 350株;耐甲氧西林的金黄色葡萄球菌和凝固酶阴性葡萄球菌分别占70.8%和82.4%,未发现耐万古霉素的葡萄球菌和肠球菌;大肠埃希菌和克雷伯菌属产ESBLs的发生率为39.2%和44.7%,产ESBLs菌株对各种抗菌药物的耐药率(亚胺培南除外)均高于不产ESBLs株;肠杆菌属对第三代头孢菌素的耐药率较高。结论 加强对细菌耐药性监测是非常必要的。

ObjectiveTo investigate the antibiotic resistance of clinical pathogens isolated in Guangzhou.MethodsThe susceptibility of clinical isolates was tested by disk diffusion method.Data were analyzed with WHONET 5.1 software.ResultsA total of 2 047 clinical isolates were analyzed,including 697 strains of gram-positive cocci and 1 350 strains of gram-negative bacilli.Strains of methicillin-resistant Staphylcoccus aureus and methicillin-resistant coagulase-negative Staphylcocci accounted for 70.8% and 82.4% respectively.No vancomycin-resistant Staphylococcus strains was identified.ESBLs-producing strains accounted for 39.2% of E.coli and 44.7% of Klebsiella.The resistance rates of ESBLs-producing strains to antimicrobial agents (except imipenem) were generally higher than those of non-ESBL-producing strains.The resistance rates of Enterobacter sp.to the third generation cephalosporins were relatively higher.ConclusionsIt is important to monitor antimicrobial resistance of clinical pathogens.