氯丁二烯对女性生殖影响的流行病学研究

Epidemiological study on the effect of chloroprene on female reproduction

对375名接触氯丁二烯女工和930名对照女工的生殖结局进行了回顾性队列研究。使用SAS程序包,采用x^2检验和非条件Logistic回归分析方法。结果表明,氯丁二烯作业女工的自然流产率(10.53％)、低体重儿出生率(14.78％)显著高于对照组(4.47％和8.22％, P<0.01)。控制混杂因素后的OR分别为1.59(95％可信限1.23～2.06)和1.37 (95％可信限1.09～1.72)。氯丁二烯引起的自然流产多发生在怀孕早期。本研究未发现其他生殖异常增多。

A retrospective cohort study on the reproduction of 375 female wor- kersexposed to chloroprene vs 930 non-exposed workers was carried out. Results were analysed by SAS,X^2 tests and non-conditional logistic regr- ession tests.Spontaneous abortion and low birth weight baby occurred in 10.53% and 14.78% of exposed female workers vs 4.47% and 8.22% in control (P<0.01).After controlling confounders,OR = 1.59 (95％CL:1.23~2.06) and OR= 1.37 (95%CL:1.09~1.72).Spontaneous abortion in exposed group mainly occurred in the first trimester of pregnancy.Other parameters of reproductive damage, such as infertility,premature delivery,congenital malformation,infant death, etc,were also studied.