托吡酯单药和添加治疗儿童癫癎的效果

Therapeutic efficiency of topiramate alone and co-administration in children epilepsy

目的:观察托吡酯对儿童各型癫疒间的临床疗效和安全性。方法:对69例癫疒间患儿进行了添加及首 次诊断单药托吡酯治疗。以应用托吡酯前3个月的发作频率或月发作≥2次发作频率为基准,与应用托吡酯达到 目标剂量后的月平均发作频率进行比较,计算有效率百分比。结果:托吡酯治疗各型儿童癫疒间的总有效率为85. 5%,单药治疗组完全控制率56.5%,添加组完全控制率47.8%。不良反应发生率为33.3%。除2例发作增多外, 大部分不良反应轻微。结论:托吡酯对儿童多种类型癫疒间有良好疗效,安全性高,可以作为儿童癫疒间一线治疗药物。

Objective:To investigate the clinical effectiveness and safety of toprimate in children epilepsy.Methods:topiramate was used in 69 children with newly diagnosed epilepsy or as supplementary therapy for those poorly controlled patients frequency of after full dose toprimate was studied based on episode 3 month before topiramate therapy or ≥2 times episode patients and then calculate effective percentage.Results:The total effectiveness of topiramate for childhood epilepsy is 85.5% with 56.5% in topiramate use alone and 52.2% in those of topiramate supplement therapy. There is 33.3% cases.in minor manifestation except 2 with frequent onset. Conclusion:Topiramate may be used as a first line drug for childhood epilepsy for its effectiveness and safety.