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基因多态性在2型糖尿病大血管病变预测中的意义 被引量:2

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摘要 2型糖尿病是一种多基因遗传性疾病 ,其大血管并发症的发生同样与遗传因素密切相关。与肥胖及胰岛素抵抗、血脂、血压、血凝等方面有关的基因多态性 ,可能在 2型糖尿病大血管病变发生的预测中起着某种作用。如何在众多的候选易感基因中筛选出最有预测价值的基因正成为今后临床与基础研究的新热点之一 ,有针对性的基因治疗亦有望成为预防 2型糖尿病大血管病变综合治疗的重要途径之一。
出处 《国外医学(生理病理科学与临床分册)》 2004年第6期505-508,共4页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
基金 国家"十五"攻关基金项目 (2 0 0 1BA70 2B0 1 2 0 0 1BA70 2B0 4) 湖南省科技厅基金项目 (0 2SSY3 0 65 )
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同被引文献19

  • 1董惠萍.抵抗素299G/A基因多态性与2型DM合并冠心病的关系[J].山东医药,2004,44(22):54-55. 被引量:1
  • 2董惠萍,闫胜利,赵世华,李长贵,王娈,綦玉琴.抵抗素基因299G/A多态性与2型糖尿病的相关性研究[J].中华糖尿病杂志(1006-6187),2004,12(6):431-432. 被引量:3
  • 3傅健,池上博司,吕远栋,徐伟红,谢海宝,荻原俊男.过氧化物酶体增殖物激活受体γ_2基因Pro^(12)→Ala可能是我国汉族人2型糖尿病的保护性等位基因[J].中华糖尿病杂志(1006-6187),2005,13(5):363-365. 被引量:19
  • 4徐伟斌,俞璐,罗敏.抵抗素的研究进展[J].国际内分泌代谢杂志,2006,26(1):23-25. 被引量:18
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