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血小板源性生长因子与早期糖尿病肾病 被引量：2

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摘要 血小板源性生长因子 (PDGF)家族是一类间质细胞和神经胶质细胞的促有丝分裂原和化学趋化剂。经典的PDGF有 2种即PDGF A和PDGF B ,近年来亦发现PDGF C和PDGF D。它们在糖尿病的肾脏表达明显增加 ,参与细胞增殖和胞外基质的合成 ,在早期糖尿病的形成和肾脏硬化中具有重要作用。
作者 王筠 邓红
机构地区 东南大学基础医学院病理学和病理生理学系
出处 《国外医学（生理病理科学与临床分册）》 2004年第6期514-516,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
关键词 血小板源性生长因子(PDGF) 糖尿病肾病 高血糖
分类号 R587.1 [医药卫生—内分泌]
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参考文献20

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同被引文献13

  • 1李伟,张红,殷松楼,褚璇.不同剂量链脲佐菌素诱导SD大鼠糖尿病肾病模型的研究[J].徐州医学院学报,2006,26(1):52-55. 被引量：55
  • 2Nakagawa H, Sasahara M, Haneda M, et al. Immunohistochemical characterization of glomerular PDFG-β chain and PDGF beta-receptor expression in diabetic rats [J]. Diabetes Res Clin Pratt, 2000, 48(2): 87-98.
  • 3KimNH, Kim K B, Kim S G, et al. Plasma and urinary vascular endothelial growth factor and diabetic nephyropaty in Type-2 diabetes mellius [J]. Diabetic Med, 2004, 21(6):545-551.
  • 4Khamaisi M, Schrijvers B F, De Vriese A S, et al. The Emerging role of VEGF in diabetic kidney disease [J]. Nephrol Dial Transplant, 2003, 18(8): 1427--1430.
  • 5Devriese A S, Tilton R G, Elger M, et al. Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes [J]. J Am Soc Nephrol, 2001, 12:993-1000.
  • 6Senthil D, Choudhury G G, Mclaurln C, el al. Vascular endothelial growth factor induces protein synthesis in renalespithelial cells: A potential role in diabetic nephyropathy [J]. KidneyInt, 2003, 64: 468-479.
  • 7EreminaV, Quaggin S E. The role of VEFG-A in glomerular development and function [J]. Nephrol Hypertens, 2004, 13(1): 9-15.
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  • 10Johnson R J,Floege J,Courser WG,et al.Role of PDGF in glomerular disease[J].J Am Soc Nephrol,1993,4:119-128.

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二级引证文献13

国外医学（生理病理科学与临床分册）
2004年 第6期

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