警惕抗结核药物引起血液系统的异常

On guard against antituberculosis drugs cause the abnormality of hematological system

目的 观察抗结核药物对血液系统的影响。方法 回顾性分析 1996年 1月— 2 0 0 4年 1月抗结核治疗中发生血液系统异常改变的 115例的临床资料。结果 4 812例结核病人抗结核治疗中发生血液系统异常改变 115例 (2 .4 % ) ,以白细胞减少最常见 (44 .4 % ) ,其次是全血细胞减少(2 2 .6 % )及白细胞合并血小板减少 (10 .4 % )。罕见有再生障碍性贫血、溶血性贫血、继发性骨髓纤维化。结论 几乎所有抗结核药物均可引起血液系统异常 ,以利福霉素类引起最常见 ,其次为吡嗪酰胺、异烟肼。既可引起血液系统中的一种有形成分改变 ,又可引起全血系统的异常 ,严重者引起死亡 ,应引起警惕。

Objective To evaluate the effects of antitubercu lo sis drugs in hematological system.Methods The clinical data of 115 pulmonary patients with the abnormality in hematological system from Jan.199 6 to Jun.2004,were reviewed retrospectively.Results In 4?812 tuberculosis cases,the abnormality in hematol ogical system were 115 (2.4%),aleucocytosis were most common existed (44.4%),th e second were pancytopenia (22.6%) and thrombocytopenia with hypolekocytosis (10 .4%).aplastic anemia,HA and SMF were seldom seen.Conclusion Almost all the antituberculosis drugs can cause abno rmality of hematological system.Rifomycins were most common next were aldinamide and isoniazide.It can cause a formed elements to change in blood.A nd cause the abnormality of whole blood,and death in serious patients cause.So it should be on guard against.