河北省1997～2002年急性弛缓性麻痹病例非脊髓灰质炎肠道病毒监测分析

Analysis of Non-Polio Enterovirus Surveillance of Acute Flaccid Paralysis Cases in Hebei Province During 1997-2002

河北省 1 997～ 2 0 0 2年急性弛缓性麻痹 (AFP)病例病毒学监测中 ,共有 2 0 2例分离到非脊髓灰质炎肠道病毒(NPEV) ,年均NPEV分离率 1 0 1 %。对分离到的NPEV毒株进行了型别鉴定 ,在明确定型的 1 0 3株NPEV中 ,包括柯萨奇病毒 (Coxsackievirus ,Cox )A组 1个型 ;Cox B组 5个型 ;埃可病毒 (ECHO) 1 4个型。RD细胞对ECHO和Cox A9敏感 ,HEp 2细胞对Cox B敏感。取消HEp 2细胞的使用 ,会造成多数Cox B和一些未能定型的NPEV漏检 ,使NPEV分离率明显降低。NPEV感染有明显的夏秋季高峰 ,主要集中在小年龄组儿童 ,以 1岁和 2岁为多。

In Hebei Province during 1997-2002,the non-polio enterovirus (NPEV)was isolated from 202 Acute Flaccid paralysis(AFP)cases,the average NPEV isolation rate was 10.1% per year. All isolated NPEVs were conducted type identification,103 strains of NPEV were identified definitely which included 1 type of Coxsackie virus (Cox.)A, 5 types of Cox.B, and 14 types of ECHO virus.RD cells were sensitive to ECHO and Cox.A9 viruses while HEp-2 cells were sensitive to Cox.B viruses.Most of Cox.B viruses and some unknown NPEV might be missed if HEp-2 cell was not used, so the NPEV isolation rate would be decreased obviously.The NPEV infection peaks were in summer and fall, and mainly among younger children, especially the children aged 1 and 2 years old.