广东省2003年急性弛缓性麻痹病例病原流行病学分析

Analysis on Pathogenic Epidemiology of AFP Cases in Guangdong Province in 2003

对广东省 2 0 0 3年急性弛缓性麻痹 (AFP)病例进行病原流行病学分析。采集 2 79例AFP病例粪便标本 ,分离到脊髓灰质炎 (脊灰 )病毒 (PV) 2 5株 ,阳性率为 8 96 %,均为疫苗株。其中PVⅡ型 1 4株 ,占 5 6 %。分离到非脊灰肠道病毒 (NPEV) 1 7株 ,阳性率为 6 0 9%。对 2 0 0 3年AFP病例的免疫史、性别、年龄与病原学结果之间的关系进行了分析 ,结果显示 :口服脊灰减毒活疫苗“零”剂次免疫的AFP病例的PV分离率依次高于 1～ 2次和≥ 3次免疫者 ,分别为 4 3 75 %、2 2 2 2 %和 2 37%;1 8例 6 0d后随访残留麻痹的病例PVⅡ分离率为 38 89%。

The pathogenic epidemiology of AFP cases in 2003 in Guangdong was analyzed. 279 stool samples were collected from AFP cases, 25 strains of polio virus (PV) were isolated and the isolation rate was 8.96%. All PV strains were vaccine-associated poliovirus. Including 14 PVⅡ strains. 15 strains of non-poliomyelitis enterovirus (NPEV) were isolated, the isolation rate was 5.39%. It was lower than that during 1994-2001 and annually gradually decreased but similar with that in 2002. After analyzing the relationships among the immunized history, sex, age, and pathogen results of AFP cases, the results showed that the isolation rate among AFP cases with zero dose immunization was higher than those among the children with 1-2 doses and 3 doses, the rates were 43.75%, 22.22%, and 2.37% respectively. The PVⅡ isolation rate of 18 residue paralysis cases after onset of disease for 60 days was higher accounting for 38.90%.