结直肠癌肝转移的治疗分析

Treatment of Hepatic Metastasis from Colorectal Cancer

目的 总结多种方法治疗结直肠癌肝转移的效果。 方法 回顾性分析 1995年 1月至2 0 0 3年 12月收治的 12 0例结直肠癌肝转移患者的治疗及生存情况。 结果 1、3年生存率 ,手术切除组分别为 83.3%和 33.3% ,经动脉化疗栓塞组分别为 5 0 .0 %和 15 .2 % ,肝动脉插管皮下埋泵术组分别为4 7.1%和 5 .9% ,冷冻治疗组分别为 5 5 .5 %和 11.1% ,综合治疗组分别为 86 .7%和 4 0 .0 %。 结论 手术是治疗结直肠癌肝转移的最佳方法 ,以个体化为原则的术后综合治疗可以提高生存率 ,降低复发率。

Objective To investigate the effect of different therapeutic approach for hepatic matastasis from colorectal cancer. Methods 120 cases with hepatic metastasis from colorectal cancer admitted from January,1995 to December, 2004 were analyzed retrospectively with regard to treatment and survival characteristics. The patients were divided into 5 groups according to different treatments including resection, transarterial chemoembolization (TACE), hepatic arterial infusion(HAI), cryotherapy (CT) and comprehensive therapy. Results The 1,3-year survival rate of the comprehensive therapy group, liver resection group, TACE group, HAI group and CT group were 86.7% and 40.0%, 83.3% and 33.3%, 50.0% and 15.2%, 47.1% and 5.9%, 55.5% and 11.1% respectively. Conclusions Liver resection can achieve best therapeutic effect for hepatic metastasis from colorectal cancer. The individualized postoperative comprehensive therapy can improve the survival rate and prevent tumor recurrence.