654—2治疗烧伤的实验研究

Experimental study of anisodmine hydrobromide for treatment of burn

为探讨654—2对大面积烧伤的治疗机理,选用S—D大白鼠制成非致死性烫伤模型,随机分为模型对照组和654—2治疗组,并设正常对照组进行对比研究。结果发现:654—2治疗组的血小板粘附率、红细胞沉降率以及血浆纤溶蛋白含量均明显低于对照组(P均<0.01)。提示654—2有改善微循环、增加局部血供、减轻组织缺氧、促进创面修复的作用。

In order to study of the therapeutic mechanism of anisodamine hydrobromide(code name 654—2)for extensive burn,non—fatal burn modols of S—D rats were reproduced and divided into control and 654—2 treated groups,in addition,there was a group of normal rats. It was found that plalete adhension rate,erythrocyte sedimentation rate and content of plasma fibrin in the treated group were significantly low as compared with control group (P<0.01). It is indicated that 654—2 plays an important role in improving microcirculation and tissue anoxia, increasing local blood supply and promoting wound healing.