共缩聚聚酰胺胶囊的制备及其性质的研究

PREPARATION AND PROPERTIES OF CO-POLYMERIZATION POLYAMINE CAPSULES

界面缩聚法是制备微胶囊的常用办法之一,在医药、农药、生物工程等各个领域得到了广泛的研究与应用.此法制备聚酰胺胶囊具有制备方法简单、缩聚速度快、囊壁孔隙大等优点.在制备胶囊时,一般以一种二元胺或多元胺作为水溶性单体,制备的微胶囊存在很大的缺陷.当用二元胺作为水溶性单体时,得到具有线型结构的聚酰胺胶囊,囊壁的机械强度差.采用多元胺作为水溶性单体时,反应深度小,制备的胶囊囊壁薄、孔隙小.我们采用二元胺和多元胺的混合物作为水溶性单体,得到了不规则缩聚的共缩聚胶囊.改变二元胺与多元胺的比例,改善囊壁的机械强度和对KCl 的渗透系数,从而制备出具有较高机械强度和较大渗透系数的胶囊,以适应实际应用中对芯材控制释放的要求.

We have prepared polyamine capsules with ethylenediamine and diethylenetri-amine or their mixtures as aqueous phase monomer,and sebacoyl chloride as oil pha-se monomer.By using cell-tensiometer,their critical tensile pressures were measured,which could contrast the tensile strength of all kinds of capsules quantitatively.Wehave also compare the porous properties of the capsules qualitatively by the permea-ble efficiencies of KCI through the capsule wall.The results showed that the tensilestrength and porous properties could be related to the proportion of ethylenediamineto diethylenetriamine monomeres.