新生儿硬肿症的血液流变学研究

Study on hemorheology in newborn with sclerema neonatorum.

【目的】研究新生儿硬肿症的血液流变学变化及其与器官损害的关系。【方法】分析36例新生儿硬肿症、36例无硬肿症患儿和30例正常新生儿的血液流变学6项指标的变化,并观察新生儿硬肿症合并器官损害的血液流变学变化。采用复方丹参和肝素治疗新生儿硬肿症,并观察其对血液流变学的影响及其疗效。【结果】新生儿硬肿症低切变、高切变全血粘度、红细胞凝集指数、红细胞刚性指数均较对照组明显升高(P<0.001),而红细胞变形性前者明显低于后者(P<0.001)。合并器官损害的新生儿硬肿症病例其全血粘度、红细胞凝集指数、红细胞刚性指数均明显高于未合并损害者(P<0.01)。【结论】新生儿硬肿症患儿血液流变学6项指标均增高,并且随病情及合并症的不同而不同。治疗时首先改善红细胞的凝集性和变形性以期减轻对器官的损害。

[Objective] To make a study on the change of hemorheology and the relations with organic lesion occurred in newborns with sclerema neonatorum. [Methods] Six indicators of hemorheological changes were analysed in 36 newborns with sclerema neonatorum (as study group), 36 sick neonates without sclerema neonatorum and 30 healthy newborns (as control group). The hemorheology changes of sclerema neonatorum were resulted in the organic lesion. Sclerema neonatorum were treated with compound root of red-rooted salvia and heparin. Their influence on the hemorheology and curative effects were observed. [Results] The low sheared and high sheared viscosity of whole blood, red blood cell aggregation index (RAI) and index of rigidity(IR) of newborns with sclerema neonatorum were clearly higher than those of the control group'(P<0. 001), however its deformability index of RBC (TK) was distinctly lower than that of the sick newborns without sclerema neonatorum (P<0. 001). The whole blood viscosity, VAI and IR of newborns with sclerema neonatorum resulted in organic lesion were obviously higher than those of no suffered from organic lesion (P<0. 001). [Conclusions] Six indicators of hemorheology in newborns with sclerema neonatorum are totally rising and vary with the different diseases and complication. In the treatment, agglutination and deformation of the red blood cells need firstly improved so as to relieve the organic lesion.