HA、PCⅢ、LN联合检测对肝纤维化的诊断价值

The Clinical Value of Combined Detection of HA、 PCⅢ、LN in the Diagnosis of Hepatic Fibrosis

目的探讨联合检测血清学指标对肝纤维化的诊断价值。方法对206例各种类型肝病患者血清HA、PC、LN进行检测,并与40例健康人做比较,分析各指标的变化特点及对肝纤维化的诊断价值。结果慢性肝炎轻型以上组3项指标均显著高于对照组和急性肝炎组(P<0.01),且3项指标随病程的进展而升高,联合检测3项指标对肝纤维化的诊断价值明显优于各单项指标。结论联合检测3项指标可提高临床对肝纤维化诊断的准确性和可靠性,动态观察上述指标对掌握病情的演变和指导治疗有重要意义。

Objective:To investigate the significance of combined detection of three serological markers in the diagnosis of hepatic fibrosis.Methods:To detect serum HA、PCⅢ、LN in 206 patients with various hepatic diseases,and to compare with 40 normal persons and analyze the variation characteristic of each marker and its significance in the diagnosis of hepatic fibrosis.Results:The three markers in chronic hepatitis (mild cases) were higher than those in control group and acute hepatitis group,and even higher than in advanced disease(moderate and severe chronic hepatitis);the three markers were obviously more precise than any single marker to diagnose hepatic fibrosis.Conclusin:Combined detection of the three markers could increase the accuracy and reliability of diagnosis of hepatic fibrosis,and dynamical observation of the three markers had very important significance in the valuation of patient′s condition and guiding clinical treatment.