大肠癌中p27^(kipl)、MMP-9的表达及相关性

Expression of p27^(kipl) and MMP-9 in Colorectal Carcinoma and Their Correlation

目的探讨p27kipl和MMP-9在大肠癌中的表达、相关性及意义。方法采用免疫组织化学SP法检测216例大肠癌组织中p27kipl和MMP-9的表达,并分析他们的相关性。结果p27kipl阳性表达率为76.9%(166/216),低表达率为65.3%(141/216);核质p27kipl共表达73例。MMP-9阳性表达率为76.9%(166/216),高表达率为65.3%(141/216)。p27kipl和MMP-9表达与大肠癌的分化程度、Dukes分期、生存期、淋巴结转移和器官转移密切相关(P<0.05)。结论p27kipl低表达和MMP-9高表达在大肠癌的进展中发挥重要作用,检测p27kipl和MMP-9的表达可能成为判断大肠癌侵袭、转移及预后的指标。

Objective:To Study the significance of expressions of p27~kipl and MMP-9 and correlation between them in colorectal carcinoma.Methods:The expressions of p27~kipl and MMP-9 in 216 colorectal carcinoma were detected by immunohistochemistry,and then the correlation between them was analyzed.Results:The positive p27~kipl expression rate was 76.9%(166/216), while low expression rate was 65.3%(141/216).Of 73 colorectal carcinoma, p27~kipl expression was positive both in nuclear and cytoplasm. The positive MMP-9 expression rate was 76.9%(166/216), while high expression rate was 65.3%(141/216). p27~kipl and MMP-9 expressions had significant correlation with differentiation extent,Dukes′ staging, survival period, lymph-node metastasis and distant metastasis(P<0.05).Conclusions:Down-expression of p27~kipl and over-expression of MMP-9 may play a key role in the development of colorectal carcinoma. The detection of p27~kipl and MMP-9 expressions could be an indicator to judge the invasion, metastasis and prognosis of colorectal carcinoma.