遗传性非息肉病性大肠癌13家系分析

Hereditary non-polyposis colorectal cancer syndrome: an analysis of 13 pedigrees

目的:探讨遗传性非息肉病性大肠癌(HNPCC)的家系特征,为早期诊断和提高治疗水平提供依据.方法:对哈尔滨医科大学第三临床医学院(黑龙江省肿瘤医院)2001-01/2002-12住院病例记录及信访、电话调查等方式查找HNPCC家系并进行分析.结果:HNPCC家系大肠癌发病年龄轻,平均为47.4(47.4±4.2)岁,右半结肠癌为主(58.5%),且转移率高(26.8%).患者亲属中大肠癌以外肿瘤以胃癌较为多见(4例).结论:黑龙江省HNPCC特点与我国其他地区报道的类似.应对HNPCC患者及其家族严密监测随访,以便早期诊断治疗.

AIM: To characteristize hereditary non-polyposis colorectal cancer syndrome (HNPCC) in assistance for its early diagnosis and treatment. METHODS: Thirteen pedigrees of HNPCC were identified and analyzed after investigations of the inpatients of the Third Clinical Hospital of Harbin Medical University (Heilongjiang Cancer Hospital) from January 2001 to December 2002. RESULTS: The patients who suffered from colorectal cancer in HNPCC pedigrees, with an average age of 47.4±4.2 years old, were younger than those from general population. Most tumors (58.5%) were located in the right colon, with a high metastatic rate (26.8%). Besides colorectal cancer, stomach cancer was also frequently occurred in the rela tives of patients with colorectal cancer (n=4). CONCLUSION: The characteristics of HNPCC in Honglongjiang Province were similar to the previous reports in other areas. Great attention should be paid to HNPCC patients and their relatives in order to make an early diagnosis and treatment.