罗格列酮(文迪雅)诱导初发2型糖尿病临床缓解的研究

The study on long-term clinical recorery induced by Rosiglitazone(Avandid) in subjects with new-diagnosed diabetes

目的 了解在解除高血糖毒性的情况下 ,胰岛素抵抗对血糖的影响和胰岛素抵抗在治疗前后 ,以及停药后的变化和长期临床缓解的可行性。方法 通过测定治疗前后空腹血糖 ,空腹血浆胰岛素水平 ,肝、肾功能 ,甲状腺功能以及餐后血糖、餐后血浆胰岛素 ,治疗前后的腰臀围比等指标 ,对治疗前后的结果进行分析。结果 经筛查共有 79例患者进入本试验组中 ,其中 5 3例患者单一服用罗格列酮 (文迪雅 )治疗 ,血糖可以达到控制目标 ,占6 7.1% ;血糖控制达标时间为 (1.9± 0 .3)周 ;空腹血糖、餐后血糖和胰岛素水平以及胰岛素抵抗指数均有显著改善。结论 单独服用文迪雅以及其与诺合龙和 (或 )二甲双胍联合使用均可以安全、有效地降低血糖 ,此途径可以作为初发

Objective To stude the insulin resistance's effect on blood glucose,the changes of insulin resistance before and after treactment and possibility of long-term clinical recorery.Methods The newhy diagnosed type 2 diabetes who reached the standavd were chosen to the study group.Fasting blood glucose,fasting plasma insulin,function of liver kidney and thyroid,prandial blood glucose,prandial plasma insulin,ratio of waist and hip before and after the treatment were measured.All the results were analysed.Results 79 patients were chosen to the study group,53(67.1%)of them only took Rosiglitazone and their blood glucose could be well controlled.If took 1.9±0.3w to control the blood glucose.Fasting,prondcal blood glucose and plasma insulin,insulin resistance index were improved significantly. After treatment of 12week ,no medicine but diet and sprorting was needed to control thr blood glucose well in the 53 patients who only took Rosiglitazone and other 9 who conlined with Noronorm.Conclusion Blood glucose could be effectively lonsered without side effect by admistide of Rosiglitazone with or without Noronorm and metformin. Sthe stratigias could be employed in type 2 diabetes.