摘要
Domain database is essential for domain property research. Eliminatingredundant information in database query is very important for database quality. Here we report themanual construction of a non-redundant human SH2 domain database. There are 119 human SH2 domains in110 SH2-containing proteins. Human SH2s were aligned with ClustalX, and a homologous tree wasgenerated. In this tree, proteins with similar known function were classified into the same group.Some proteins in the same group have been reported to have similar binding motifs experimentally.The tree might provide clues about possible functions of hypothetical proteins for furtherexperimental verification.
Domain database is essential for domain property research. Eliminatingredundant information in database query is very important for database quality. Here we report themanual construction of a non-redundant human SH2 domain database. There are 119 human SH2 domains in110 SH2-containing proteins. Human SH2s were aligned with ClustalX, and a homologous tree wasgenerated. In this tree, proteins with similar known function were classified into the same group.Some proteins in the same group have been reported to have similar binding motifs experimentally.The tree might provide clues about possible functions of hypothetical proteins for furtherexperimental verification.
基金
This work was partly supported by grants from Na-tional Natural Science Foundation of China (No.3037030
30270657 and 30230150)
Major State Basic Research Development Program of China(2004CB520804)
Pilot Study for Key Basic Re-search Project of China (2002CCA04100)
and Key Project for International Cooperation of China (2002AA229031).
