二氢沉香呋喃类化合物结构——活性关系的初步研究

PRELIMINARY STUDIES ON THE RELATION OF STRUCTURE —— ACTIVITY OF DIHYDROAGAROFURAN COMPOUNDS

选择从卫矛科南蛇藤属植物中分离的11个二氢沉香呋喃类纯化合物进行了结构——活性关系的初步研究。结果表明,C—4位控基对昆虫的拒食活性贡献最大;C—12位的异丁酸酯基可能是对昆虫具有毒杀作用的主要活性基团,而且在差向异构体中,β型的活性显著高于α型;C—8、C—9位的呋喃甲酸酯基配合C—12位的异丁酸酯基可能对昆虫的麻醉活性起重要作用。

The studies on the relation of structure-activity of 11 dihydroagarofuran compounds from Celastraceae Plants have been carried out in our laboratory. The results indicated that the hydroxy at C—4 was responsible for the antifeeding activity, that the isobutanoyloxy at C—12 might be an important poisonous active group, moreover, the β configuration was more active than the a configuration for a pair of isomers. The results also showed that the furancarbonyloxy at C—8, C—9 companied by isobutanoyloxy at C—12 might play an important role in narcotic activity.