摘要
目的 探讨中晚期食管癌术前放化疗提高手术切除率及临床疗效。方法 将中晚期食管癌 5 5例患者随机分为术前放化疗组 (A组 ) ,单纯手术组 (B组 )。A组患者术前 1周应用盖诺 +DDP方案化疗、4周DT 4 0Gy的病灶及区域淋巴结放疗 ,间隔 2周后手术 ,B组单纯手术治疗。结果 A组手术切除率及生存率与B组比较结果有显著性差异 (P <0 .0 5 )。结论 术前放化疗在提高中晚期食管癌手术切除率及生存率等方面具有临床意义。
Objective To investigate the i mp act of preoperative chemoradiotherapy in advanced esophageal carcinoma in terms of improving the resection and survival rate. Method 55 patients with advanced esophageal carcinoma were divided randomly into group A (preoper ative chemoradiotherapy) and group B(operation only). Group A underwent 1 week c ycle of vinorelbine bitartrate injection combined with DDP chemotherapy and 4 weeks D T 40 Gy radiotherapy, then operations were performed. Group B underwent operatio n d irectly. Result The resection and survival rate in group A were su p erior to that of group B (P<0.05). Conclusion Preopera tive chemoradiotherapy has effect in advanced esophageal carcinoma.
基金
潮州市科技局社会发展计划立项课题 :编号 2 0 0 2S0 9
