还原型谷胱甘肽对急性胰腺炎全身炎症反应综合征的治疗作用

Therapeutic effect of reduced glutathione on systemic inflammatory response syndrome with acute pancreatitis

目的 探讨还原型谷胱甘肽对全身性炎症反应综合征 (SIRS)的治疗价值。方法 将 4 5例急性胰腺炎伴SIRS的患者随机分为治疗Ⅰ组和Ⅱ组 ,设正常对照组 2 0名。治疗Ⅰ组加用还原型谷胱甘肽 1 2g d静脉点滴 ,其余两组治疗相同。于治疗前和治疗后测定血浆肿瘤坏死因子 (TNF α)和白细胞介素 6、 8(IL 6、IL 8)及检测血糖、血钙、ALT、血 尿Ams等 ,并按SIRS诊断标准观察临床病情。结果 治疗Ⅰ组治疗SIRS有效率达 95 5 % ,明显高于治疗Ⅱ组 ;且血糖、ALT也较治疗Ⅱ组明显恢复 (P <0 0 5 )。两组治疗后TNF α,IL 6 ,IL 8均较治疗前下降 ,而治疗Ⅰ组较Ⅱ组下降更显著 (P <0 0 5 )。

Objective To study the therapeutic effect of reduced glutathione hormone(GSH)on systemic inflammatory response syndrome(SIRS)with acute pancereatitis.Methods 45 SIRS patients with acute pancreatitis were randomly divided into two groups:treatment group Ⅰ,twenty-two patients were given GSH of 1.2g per day through intravenous drip for 7 days;treatmene group Ⅱ,twenty-three patients were not given GSH.The effective rate of SIRS groups were given the same treatment besides GSH.TNF-α,IL-6 and IL-8 were measured.Results The effective rate of SIRS was 95.5%in treatment group Ⅰ and 73.9%in group Ⅱ(P<0.05).The consentration of blood glucose and alanine aminotransferase(ALT)in group Ⅰ were more decreased than those in group Ⅱ(P<0.05).After administration,the levels of TNF-α,IL-6,IL-8 were significantly decreased in both treatment groups(P<0.05).The levels of TNF-α,IL-6,IL-8 in treatment group Ⅰ were decreased much more obviously,compared with those in group Ⅱ(P<0.05).Conclusion These findings seem to indicate that exognous GSH might be a useful drug in the treatment of SIRS.